The company Knauer Wissenschaftliche Geräte GmbH was nominated as one of ten companies for the coveted innovation award with its innovation “Impingement Jets Mixing Skids for high-flow production of lipid nanoparticles – for the production of the Corona mRNA vaccine”. The announcement was made on September 8, 2021, at a press conference held at Unicorn Workspaces in Berlin’s Brunnenstraße.
The efficacy of mRNA vaccines against Corona relies on encapsulation of the sensitive mRNA in so-called lipid nanoparticles. Encapsulation systems existed only on the smallest laboratory scale worldwide until the fall of 2020. In cooperation with two large pharmaceutical companies, the company has succeeded in a very short time in developing flexible systems, so-called IJM skids (Impingement Jet Mixing), with which lipid nanoparticles for several million vaccine doses per week can be produced.
In addition to mRNA-based vaccines, pharmaceutical companies are working on mRNA-based drugs for a variety of diseases, including Alzheimer’s, HIV, malaria, and others. The best known of these is BioNTech, which is researching a therapy against cancer. These drugs, in order to reach cells intact, must be encapsulated in lipid nanoparticles. As a result, IJM skids of varying sizes will continue to be needed to fight diseases worldwide.
“I am pleased that we were able to successfully deliver all of our systems for vaccine production on time. It makes our team proud that we are contributing to the fight against COVID-19 in this way.”
– Lilit Avagyan, Business Development Manager
German Chancellor Dr. Angela Merkel paid a visit to the company on September 10, 2021. Alexandra Knauer, the managing director and owner of the family-owned business with 160 employees, together with her managing director Carsten Losch, welcomed the Chancellor. From a press statement by Chancellor Merkel, the following emerges (excerpt):
“I was very pleased to visit this company today because the highest precision technology is being developed here, especially now their latest product – after the company has been developing for many decades – something that was urgently needed in the development of the mRNA vaccines or rather for the production of the mRNA vaccines on a large scale.”
The Group has created additional jobs for the production of the LNP systems at its site in Berlin-Zehlendorf – fifteen will be created in 2021.
The jury of the Berlin Brandenburg Innovation Award, chaired by Prof. Oliver Günther, Ph. D., President of the University of Potsdam, selected the ten best innovations in the capital region as nominees from 168 applications in the competition for the Berlin Brandenburg Innovation Award.
Advanced analog IC foundry process technologies
Now, Siemens Digital Industries Software announced that its new mPower™ solution for power integrity analysis of analog, digital and mixed-signal integrated circuit (IC) designs has now been certified for Tower Semiconductor’s SBC13 and SBC18 process technologies.
This software is the industry’s first IC power integrity verification solution that offers virtually unlimited scalability for analog, digital and mixed-signal ICs and provides comprehensive power, electromigration (EM) and voltage drop (IR) analysis for even the largest IC designs.
“Siemens is proud that Tower Semiconductor, an industry leader in analog technologies, has now certified mPower for the SBC13 and SBC18 processes it offers. This solution, developed collaboratively by Tower Semiconductor and Siemens, contributes to more accurate and faster EM/IR analysis for joint customers. This, in turn, results in shorter time-to-market and higher quality end devices.”
– Joseph Davis, Senior Director
With this technology, IC designers can more quickly and thoroughly verify that their analog and mixed-signal designs meet performance-based design goals – capabilities that help IC customers dramatically improve quality, increase reliability and shorten time-to-market.
With the PlusClean tank cleaning nozzle, Alfa Laval sets a new standard for hygienic fluid handling in the food, dairy, beverage, pharmaceutical and personal care industries. Users achieve 100 percent cleaning coverage, which is unique in the market. In addition, up to 80 percent water and detergent savings can be achieved compared to conventional methods.
The cleaning nozzle works in tandem with primary tank cleaning equipment such as rotating spray balls or jet cleaners. Depending on the design of the tank, the nozzle can be easily integrated flush into the wall or floor. When activated by the cleaning medium or, optionally, the air drive, it removes contaminants below the agitator blades and in other areas in a fan-shaped pattern.
Controlled and repeated rotation of the agitator shaft and blades ensures 100 percent cleaning coverage. Even the shadow areas below the agitator blades, heating or cooling coils and connections, which are inaccessible to top-mounted tank cleaning equipment, are reliably hit. When the cleaning cycle is complete, the integrated drive returns the piston to its original position, securely closing and sealing the cleaning device.
Contamination risks are minimized by thorough tank cleaning with PlusClean. Faster and safer changeovers increase the productivity of batches or continuous processes.
In the middle of Lower Saxony’s Wadden Sea lies Norderney – a sea that has been a UNESCO World Heritage Site since 2009. The East Frisian island is a climatic health resort and spa. That’s why freight forwarder Georg Fischer has recently turned to electromobility. A native of Norderney, he is the fourth generation of his family to run the island haulage company “Johann Fischer”. His fleet includes 35 MAN vehicles – among them several semitrailer tractors and, since about a quarter of a year, three MAN eTGEs. With the electrically powered transporters, he wants to set an example. Holidaymakers are very nature-conscious, he says, and Norderney is known throughout Germany.He is one of the first companies on the North Sea island to switch to electric mobility.
“If we set a good example here, that radiates out.”
– Georg Fischer
Vehicle fleet for transporting goods on the islands
Georg Fischer is a “reception forwarder” for Norderney and the other East Frisian islands. Its core business is distribution services along the North Sea coast. He operates a large warehouse in the town of Norden, where the other forwarders unload their goods, and delivers them to the ferries six days a week with his own vehicles. He also travels for grocery and drug store chains. He picks up the goods from their central warehouses and then transports them to the stores on the islands. He even transports building materials with his fleet of vehicles specially tailored to the island. 85 employees are on the road for him and active in the warehouses in Norden and on Norderney.
Delivery service to the hotel
Since larger trucks are allowed to cross the island by ferry but are not allowed to drive across the island, the freight forwarder handles the goods directly in the warehouse at Norderney harbor. From the articulated trucks, they are loaded onto smaller vehicles – including the battery-electric transporters that take drinks, food and parcels from the warehouse through the narrow alleyways to the hotels, guesthouses and stores. The suitcases of the vacation guests are also delivered directly to the vacation domicile by the electric transporters.
For Georg Fischer, the three vehicles are an ideal addition to its fleet. The range of up to 130 kilometers is absolutely sufficient for the distances on the island. Often, one battery charge is enough for two full days of work. The three vehicles are charged at wallboxes directly at the warehouse. The eTGEs are quiet and hardly disturb the tourists who are looking for peace and quiet on Norderney, says Georg Fischer. He is also convinced of the driving comfort: “You quickly get used to the electric drive. After all, an all-electric van like this has no gearshift and delivers full power to the axle.” In addition, he says, the eTGEs offer the comfort he has been used to for many years. “I am absolutely convinced of the quality of my vehicles, the workmanship, the reliability – nothing squeaks or creaks,” he says.