Inspection of lyophilized products

Lyo-Check is an auto­mat­ic indus­tri­al machine designed for the visu­al inspec­tion of lyophilized phar­ma­ceu­ti­cal prepa­ra­tions intend­ed for injec­tion (par­enter­alia). The Lyo-Check, with a capac­i­ty through­put up to 600 containers/minute, has two com­ple­men­tary sys­tems in order to per­form a total inspec­tion of the vial and of the lyophilized content:

• Visu­al inspec­tion tech­nol­o­gy for par­ti­cle check­ing, fill­ing lev­el check­ing, con­tain­ers cos­met­ic and func­tion­al faults detection;
• Cap clo­sure integri­ty using laser absorp­tion spec­troscopy Head Space Gas Analy­sis in order to test the steril­i­ty of containers
• Cap clo­sure integri­ty using laser absorp­tion spec­troscopy HSGA

Reject ver­i­fi­ca­tion sys­tem based on “fail-safe” prin­ci­ple ensures that con­tain­ers rec­og­nized as defec­tive will not reach the chan­nel of good prod­ucts. The machines can be run by a sin­gle oper­a­tor through the built-in touch-screen dis­play, where all the con­trols and con­fig­ur­ing func­tions are available.

Disruptive technology, patented solutions

Exclu­sive main inspec­tion carousel design fea­tures a com­bi­na­tion of grip­pers and col­umn-free con­fig­u­ra­tion. A patent pro­tects the con­fig­u­ra­tion of the main inspec­tion carousel which is designed with­out cen­tral col­umn allowing:

• the cam­eras to be placed at a big­ger dis­tance from the object, thus obtain­ing the per­fect focus with­out need for re-adjustment;
• the light­ing source to be placed on dif­fer­ent sides around the prod­uct to be inspect­ed (rather than just one side);
• cam­eras to be angled (rather than point­ing straight at the product)

High precision cap inspection

Dynam­ic seal inspec­tion for the qual­i­ty of the crimped alu­minum seal of the vial using sec­ond carousel. A patent has been filed for a spe­cif­ic design of a new type of inspec­tion sta­tion ded­i­cat­ed to crimp­ing and neck inspec­tion. The sta­tion is based on a dynam­ic inspec­tion which exploits and exter­nal tur­ret (or sec­ond carousel) com­posed of a series of cam­eras and at least two type of light­ing source: from the top and from the bot­tom. Each light types has there­fore a dif­fer­ent angle of inci­dence ver­sus the zone to be inspect­ed and allows for the cre­ation of a dif­fer­ent envi­ron­ment, help­ing to max­i­mize the defect visibility.