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“Green” building for meeting needs of customers and employees 

Endress+Hauser Canada has built one of the “greenest” company buildings in the country for 20 million euros. The newly opened customer and training center in Burlington/Ontario, located around 50 kilometers southwest of Toronto, is energy self-sufficient and CO2-neutral. A process engineering training facility, a large calibration laboratory, a workshop, a training center and around 120 modern workstations have been accommodated on 4,400 square meters of floor space – double the previous location. 

The company has had its own sales company in Canada since 1990, serving customers from Manitoba to the Atlantic provinces. The employees at the headquarters in Burlington and in branches in Montreal, Calgary and Edmonton are supported by various representatives. Whether basic materials, metals & mining, oil & gas, food, chemicals, life sciences, water & wastewater, energy & power plants – virtually all industries are at home in this resource-rich country. 

New building stands for brand values 

“The customer and training center is an impressive example of Endress+Hauser’s global strategy of building and maintaining customer partnerships. This is how we grow, in Canada and around the world. It shows our commitment to customers and our dedication to sustainability.” 

– Matthias Altendorf, CEO

Statement to the public 

“The new building should express our aspirations as a company – to our customers, but also to the public as a whole,” emphasizes CEO Anthony Varga. During the planning process, the focus was on the needs of the customers. “We can support customers here in the best possible way throughout the entire life cycle of their facilities. We offer a welcoming environment and set standards with the ecological building design.” 

Practical training 

At the heart of the new building is a process training unit; the second facility of its kind in Canada. Such Process Training Units (PTU) exist at Endress+Hauser sites around the world. At these pilot plants, customers can practice using a wide range of measuring instruments. They benefit from the long-standing partnership with Rockwell Automation and other manufacturers. Customers can thus simulate conditions on the plant that are similar to their own operations. 

Renewable energy 

The Group places great emphasis on sustainability and energy efficiency in construction projects all over the world. The new building in Canada covers its electricity needs via 800 solar modules on the roof. These can generate around 408,000 kilowatt hours of electrical energy per year. This exceeds the building’s needs, so electricity can be fed into the grid. A geothermal system extracts heat via 50 wells from a depth of 180 meters and distributes it throughout the building via 63 heat pumps. 

Sophisticated architecture 

South-facing windows on the upper floor capture sunlight, and the triple-glazed facade prevents heat loss. A four-meter-high ficus tree in the atrium improves air quality and symbolizes the “green” idea. Thanks to all these measures, the building is one of the greenest structures in the country. It is the first private company to seek all three certifications from the Canada Green Building Council: the Net Zero Energy and Zero Carbon Building Standards, and Leadership in Energy and Environmental Design (LEED) Gold. 

News Operation & Maintenance Processing Technologies

Stabilization of plastic exhaust systems during implementation

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According to the exhaust specialist ATEC from Neu Wulmstorf, the Vario roof flange can be mounted on all roofs with high fitting accuracy. The selection is based on the roof pitch and the required nominal size. In addition, the flange is suitable for temperature classes T200 and T250 – and ATEC has had this certified with a general design approval.

The new product combines two components: first, the flange itself, which provides a stable connection between the roof elevation and the roof structure, and second, the optional seal, a self-adhesive vapor retarder. The company provides two versions: for roof pitches between 0° and 30°, and from 30° to 60°, each in eight nominal sizes between DN60/100 and DN250/315. It is also compatible with plastic and metal exhaust systems up to a nominal operating temperature of ≤ 250 °C.

The flange consists of a stainless steel clamp to which two retaining lugs/articulated brackets are welded at the factory. This is accompanied by a cover plate measuring 450 x 450 mm and 0.5 mm thick. With the help of malleable perforated strips, the exhaust pipe together with the Vario roof flange is screwed into place. This allows the Vario to be used flexibly both in new buildings and in existing properties.

 

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News Operation & Maintenance Processing Technologies

Modern user interface impresses international jury

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SIG’s new intuitive Human Machine Interface (HMI) “SIG CRUISER” has been awarded the prestigious iF DESIGN AWARD 2022 in Gold – one of the most important design awards in the world. This part of SIG’s next-generation filling technology enables customers to easily control their entire production process. The user interface is designed to make the operator’s job much easier, while reducing the need for training and prior experience.

The award has been presented annually since 1954 by the iF Industrie Forum Design for outstanding achievements in product design. The company impressed the 132-member jury, which is made up of independent design experts from around the world, and won the award in the “User Interface (UI)” category. Out of nearly 11,000 entries, SIG CRUISER was awarded gold as one of 73 outstanding design achievements.

The judges made the following statement, “With a user-centric approach and sound development methodology, SIG CRUISER provides consistency from the store floor to the top floor, ensuring quick response times and convenience for both the operator and the service team. The user interface is exceptionally simple and user-friendly in terms of operations, layout and graphics, allowing a single operator to control the entire line.”

Today’s competitive environment requires companies to increase production and margins and optimize available equipment. To get the most out of filling lines, it is critical to reduce the risk of downtime and to interconnect, automate and monitor lines for maximum efficiency. The new user interface makes it possible to control the entire filling line. It displays KPIs in an intuitive way.

“This prestigious global design award is the result of the good cooperation between SIG and our partner, HMI Project GmbH. We are very proud that SIG CRUISER stood out from thousands of submissions and convinced the 132-member jury to award an iF DESIGN AWARD in Gold.”

– Stefan Mergel, Senior Product Manager Equipment

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Ingredients & Auxiliary Materials News Pharmaceuticals Processing Technologies

Innovative insights into emergence and classification into subtypes

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One of the deadliest tumor types is pancreatic cancer . The disease is often only discovered in locally advanced or metastasized tumor stages, when surgical intervention comes too late. Researchers led by Dr. Ivonne Regel of LMU Klinikum in Munich have now gained important new insights into the causes of tumor development. They have also succeeded in defining different tumor subtypes based on differences in their metabolic programs. Funded by the Wilhelm Sander Foundation, they are thus making a significant contribution to early detection and to individualized medicine in order to improve the chances of recovery for pancreatic cancer patients.

Pancreatic ductal adenocarcinoma, also known as pancreatic cancer, is a relatively rare but particularly malignant disease. It represents the fourth leading cause of cancer-related deaths in the European Union, and only about 10 percent of patients survive the first five years after diagnosis. This is due to aggressive growth and late diagnosis of the tumor. Pancreatic cancer often manifests itself only after other organs have already been affected and metastases are present. To improve the chance of cure for pancreatic cancer patients, it is of great urgency to find new biomarkers for early detection. Another essential step is to identify tumor-specific signaling pathways that cause aggressive disease progression in order to identify new targets for therapeutic approaches.

TLR3/IRF3/IRF7 signaling pathway critical for pancreatic cancer development

Pancreatic cancer development is a dynamic process involving tissue damage and inflammatory response in the pancreas. When pancreatitis occurs, the organ has a self-healing mechanism. Normal pancreatic cells can divide to replace damaged tissue. Molecules released during inflammatory and tissue-damaging processes are recognized by cell receptors, relaying signals that promote cell survival and division.

However, in pancreatic cells, this can contribute to cell degeneration and promote the development of pancreatic cancer. Researchers led by Dr. Ivonne Regel were able to show for the first time that the signaling pathway plays an important role in inflammatory responses not only in immune cells, but is also active in pancreatic cells of precursor lesions and tumor cells. This activation of the signaling pathway has an important function in pancreatic cancer development. Genetically-altered mice lacking a functional signaling pathway are unable to develop pancreatic carcinomas (see Figure). Similarly, it was genetically knocked out in pancreatic tumor cells using CRISPR/Cas9 gene scissors. These genetically modified tumor cells exhibited significantly less aggressive behavior in cell culture experiments and also showed greatly reduced metastasis in animal models.

“For the first time, we were able to demonstrate that an active signaling pathway in pancreatic cells contributes to the development of pancreatic cancer and also supports the formation of metastases.”

– Ivonne Regel

Dr. Regel’s team has made another exciting discovery: In pancreatic tumor cells, the signaling pathway surprisingly does not regulate known target genes; instead, evidence was found for epigenetic modifications. These are regulatory modifications to DNA and packaging proteins (histones) that influence the activity of genes. Thus, the current research results indicate that activation of the signaling pathway in tumor cells leads to high levels of transcription of specific tumor-promoting genes.

These genes primarily regulate tumor cell metabolism. This is particularly important because metabolites of tumor cells can be found in the blood of patients and can be used as biomarkers. “My team and I have succeeded in identifying different subtypes of pancreatic cancer from the blood of cancer patients based on differences in their metabolic programs” said Dr. Regel. “In further studies, we now want to find out to what extent the development of pancreatic cancer subtypes is regulated by the signaling pathway.”

 

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