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Eli Lilly’s acquisition of Loxo Oncology

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News, Pharmaceuticals

Eli Lilly’s acquisition of Loxo Oncology marks the second multibillion-dollar deal in 2019 following the recent BMS and Celgene merger.

“Eli Lilly’s choice of Loxo is highly strategic due to Loxo’s unique oncology portfolio as well as its potential for quick return of investment. To this end, Lilly will immediately collect sales revenues from Loxo’s recently branded first-in-class tropomyosin receptor kinase (TRK) inhibitor Vitrakvi (larotrectinib).

Vitrakvi’s strength comes from its first-to-market advantage, as well as its label, as it is approved based on the presence of a biomarker, neurotropic receptor tyrosine kinase (NTRK) fusion in tumors rather than location of the tumor. This means that the drug can be readily used in more than 17 different types of advanced cancers that are driven by NTRK fusions.

Loxo’s follow up second generation TRK inhibitor, LOXO-195, is designed to address the potential acquired resistance that could emerge in patients receiving Vitrakvi. The two agents will therefore allow Lilly to dominate the treatment paradigm in NTRK fusion driven cancers.

A second gem in Loxo’s clinical pipeline is LOXO-292, an inhibitor of rearranged during transfection (RET) kinase. Already granted a breakthrough therapy designation in RET-fusion positive NSCLC and RET–mutation positive medullary thyroid cancer, LOXO-292 will soon be Lilly’s second brand inherited from Loxo. Similar to Vitrakvi, LOXO-292 is first in its class and is expected to become the first branded RET inhibitor.

Ultimately, the deal will help Lilly replenish and diversify its oncology portfolio, which is losing ground due to the impending patent expiration and increasing market competition facing its leading oncology brands Alimta, Cyramza, and Verzenio.”

Volkan Gunduz, PhD, Senior Oncology and Hematology Analyst at GlobalData

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Expansion of the Lyon location
Expertise for advanced analysis

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Advanced analysis: Endress+Hauser expands competence center in Lyon. Picture: Endress + Hauser
Advanced analysis: Endress+Hauser expands competence center in Lyon. (Picture: Endress + Hauser)

Endress + Hauser has expanded its center of competence for advanced analysis in Lyon, France. The Group invested 2 million euros in a new production facility and office space to meet the growing demand in the area of advanced process analyses.

From Lyon, around 20 employees support Endress + Hauser sales centers across Europe in the application and sales of advanced analysis technology, with a focus on the project business and after-sales services. Ten sales centers across Europe already have specialists on board to handle this complex field of activity.

Customer-specific manufacturing

The new 630-square-meter production facility will be used for customer-specific manufacturing and the assembly of complete analysis systems. Rounding out the facility are offices, rooms for factory acceptance tests and space reserved for future use. The adjacent 1,500-square-meter office building, which opened in 2017, is also home to the Endress + Hauser France regional sales office. With a total of 7,000 square meters, the property offers sufficient space to grow the location even further.

Strategic focus

“The expansion of the Lyon location allows us to do an even better job of bringing our expertise in the field of process analysis to our customers,” emphasized Matthias Altendorf, CEO of the Endress + Hauser Group, during the dedication ceremony on 17 July 2019. “This is an important strategic goal for us and helps our customers acquire more information from their processes.”

Analysis portfolio expands

Advanced analysis provides immediate information related to material properties and product quality. The company continuously develops its analysis portfolio to provide online monitoring of quality parameters, for example through spectroscopic techniques. This allows customers to reduce time to market and optimize their processes. Customers in industries such as life sciences, chemical, food & beverage and oil & gas can benefit the most from Endress + Hauser’s advanced analysis portfolio.

Advanced technologies

The Lyon location combines the expertise of the firm and its subsidiaries Kaiser Optical Systems and SpectraSensors under one roof. The Raman analyzers from Kaiser Optical Systems are used to examine the composition and material properties of liquids, gases and solids and enable the real-time measurement of product characteristics. SpectraSensors is a leader in the field of TDLAS technology, which can be used to reliably measure trace-level concentrations of gases.

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N-ARPEX
New clutch generation

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Flender-Kupplung-N-ARPEX

Special couplings for particularly demanding applications in the industrial sector. The new clutch generation from Flender: More power. More effectiveness. Cost less.

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Compact industrial barcode printer
Top drawer label printers

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TSC Auto ID Technology EMEA Top drawer label printers
Picture: TSC Auto ID Technology

Space-saving footprint like a desktop printer due to downsized dimensions, but powerful as an industrial printer – TSC’s new ML240P series covers exactly the niche of high demand in the market. Both versatile top-class all-rounders impress with their strong connectivity features and excellent printing quality while being extremely economical and flexible. The two models are equipped with a clear colour display ensuring a high operating comfort.

The thermal transfer printers ML240P and ML340P will be available on the EMEA market from June 2019. In comparison to the already very compact TSC models in this sector the dimensions of this new generation of high-performance industrial label printers have been reduced again significantly.

The intelligent combination of solid metal housing including media spindle, modularized base and modern printing technology enables a permanently steady, low-noise and at the same time highly efficient operation even with demanding applications. The adjustable longlife thermal printhead and self-diagnostic TPH Care mechanism ensure optimal print quality with various label materials. Bad dot detection offers the user peace of mind by alerting them to any pins in the head which might have blown – which otherwise would repeatedly produce unreadable barcodes without any way of noticing before it came to scanning.

The ML240P is available in 203 dpi printing resolution, the ML340P is available in strong 300 dpi printing resolution. Besides comprehensive sensors and modern interfaces, both models in particular also provide the user with a high definition 2.3” colour display with intuitive, customizable operator guidance and six menue buttons as prominent standard features.

Material changes can be realized quickly because the cover can be lifted up entirely. Due to the sophisticated printing mechanism the replacement of printhead and platen roller is possible without the need of tools, saving time and reducing cost of ownership.

With their small footprint of just 818 cm² the new reliable printers can also be used in restricted working environments where space is a premium. The range of applications is not limited for the ML models: The spectrum ranges from use in warehousing and logistics including goods in and despatch to manufacturing as well as to product- and shelf-labelling in retail and labelling of sample tubes and patient wristbands in the health sector.

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