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► Achema

Pharmaceutical industry
Coding solutions for the serialisation

Innovative coding solutions for the serialisation requirements of the pharmaceutical industry
Picture: Domino

February 9, 2019 and the associated serialisation requirements are imminent.

In this the key role of high-quality and long-term readable labelling is of central importance.

At Achema, hall 3.1, stand F58, Domino will showcase future-proof coding, marking and labelling solutions which guarantee simple, successful and compliant marking solutions on a multitude of substrates and packaging types.

The innovative coding and marking systems enable meeting the validation requirements for GMP (good manufacturing practice) as well as implementing global legislation standards such as the EU regulation 2016/161 to execute the Falsified Medicines Directive 2011/62/EU, the EU Medical Device Regulation 2017/745, 21 CFR Part 11, e-Pedigree, SFDA, ANVISA and the US FDA UDI.
Domino also provides trusted solutions for aggregation, i.e. the establishment of data connection at each stage of the packaging process, is required.

With a focused approach, Domino has become the preferred strategic provider of marking solutions to numerous manufacturers and OEMs.

Our product portfolio comprises innovative thermal ink jet (TIJ) printers with inks especially developed for the industry, laser coders, Continuous Ink jet (CIJ) printers, Thermal Transfer Overprinters (TTO) as well as Print and Apply labelling machines (PALM).

Domino at the Achema 2018: hall 3.1, stand F58

► Achema Mechanical Processes Pharmaceuticals

Xelum R&D
From the lab to continuous production

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The new R&D device for the continuous production of oral solid dosage (OSD) forms ensures short time to market and an optimum dosing of smallest amounts of API.
The new R&D device for the continuous production of oral solid dosage (OSD) forms ensures short time to market and an optimum dosing of smallest amounts of API. (Picture: Bosch)

At Achema 2018, Bosch Packaging Technology unveiled its latest R&D device for the continuous production of oral solid dosage (OSD) forms. The platform ensures a short time to market and optimum dosing of APIs. “The new laboratory device is based on our Xelum production platform that we presented last year,” says Fritz-Martin Scholz, product manager at the Bosch subsidiary Hüttlin. “The separated process steps of batch production take place one after the other and without interruption. This leads to shorter cycle times, lower production costs and high flexibility.” With the Xelum R&D, the company offers a platform that offers an ideal start to continuous manufacturing.

Precise and reliable dosing

As opposed to the common complex mass flow rate, excipients and active ingredients are dosed as a discrete mass in the Xelum R&D. This makes it possible to dose even smallest amounts of APIs of less than one percent. The system doses, mixes and granulates individual packages, so-called X-keys, which continuously run through the process chain and are removed successively from the machine as packages into bins. “This way we reduce not only process complexity, but also the system’s failure susceptibility, while increasing both accuracy and quality of the end product. Moreover, the product is traceable at all times,” says Scholz. Depending on requirements, up to four loss-in-weight feeders can be used.

The benefits of the fluid bed

Current continuous production systems for wet granulation mostly use twin screw granulators. The Xelum system relies on fluid bed processors – based on a proven technology developed by Hüttlin. In the fluid bed, granulation and drying take place in the same process chamber. “This eliminates the need to transfer wet granules, which in turn has a positive effect on the system’s reliability,” Scholz emphasizes. Pharmaceutical manufacturers obtain granulates with the desired characteristics – including unimodal particle size distribution, as well as excellent flow and tableting properties combined with high production yields.

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► Achema Measurement, Instrumentation, Control & Automation

Industry 4.0 Applications
Condition Monitoring and Predictive Maintenance

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At Achema 2018, Pepperl+Fuchs showed several possible applications for the realization of end-to-end communication from the field to cloud-based data platforms. In addition to its well-known and proven products, Pepperl+Fuchs offers an agile development partner for innovative IoT solutions in the form of its subsidiary, Neoception.

IIoT for Process Automation

Ethernet for Process Automation. Picture: Pepperl+Fuchs

Ethernet for Process Automation. (Picture: Pepperl+Fuchs)

As part of “IIoT for Process Automation,” Remote I/O from Pepperl+Fuchs is used to map field devices—such as control valves and flow measuring instruments—in existing plants, along with all relevant data, in the SAP Cloud Platform. The parallel transmission path is completely independent from the control system connection and therefore complies with the Namur Open Architecture framework.

Ethernet for Process Automation

“APL—Ethernet for Process Automation” brings Ethernet connectivity to every aspect of every plant. The two-wire cable (cable type A), familiar from Profibus PA, serves as a physical layer for Ethernet, allowing the use of all established protocols such as HTTP, FTP, etc. with a transfer rate of 10 Mbit/s. The robust line can bridge distances of up to 2000 m, while also supplying field devices, even in explosion-hazardous areas up to Zone 0/Div. 1.

Connecting Any Field Device

Using the concept developed by Neoception and CodeWrights, data from any field device can be very quickly made available on a data platform. No complex engineering processes are required and the users do not need in-depth knowledge of the transmission technology, allowing them to concentrate fully on selecting and evaluating parameters.

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► Achema Pumps & Compressors

Drive Pump
New feature for the MNK pump

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The Biggest Lined Mag Drive Pump Got Even Better
Picture: Richter Chemie-Technik

At the 2006 Achema, Richter Chemie-Technik impressed the specialized audience by announcing the largest fluoropolymer-lined, magnetically driven centrifugal pump. This pump made it possible to move flow rates up to 600 m3/h and achieve delivery heights up to 60 m. Being able to control these operating conditions with this new product inevitably led to increased demand from the end-user. These ranged from the density of the conveyed product, temperature and flexible delivery rates from the partial load range to the overload range.

These increased demands, especially in the partial load range, require optimization of the impeller to control forces, vibration and noise emission.

Existing impellers can be easily replaced due to identical hydraulic performance against the previous “Standard Hydraulics II”. This improvement makes the biggest lined magnetic pump even more powerful and reliable in the most critical applications.

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